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Mectizan Expert Committee Statement on Potential Efficacy of Ivermectin on COVID-19

A report by Caly et al found that ivermectin has shown in vitro activity against SARS-COV-2 (COVID-19) in tissue culture with Vero-hSLAM cells. These findings are consistent with the activity of ivermectin previously reported against other viruses in vitro. However, the high concentration of ivermectin needed to produce anti-viral effects in laboratory tissue culture is far beyond dosage levels approved by the FDA for treatment of parasites in humans and known to be safe and well tolerated. Furthermore, the concentration is many times higher than dosage levels ever tested in humans. High doses in animal models have produced serious toxicity. These preliminary laboratory findings in tissue cultures are not sufficient to indicate that ivermectin will be of clinical benefit to reduce viral loads in COVID-19 patients.

Caly, L., et al., The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral research, 2020.

News, videos & resources

Get the latest on the Mectizan Donation Program

2019 Mectizan Donation Program Annual Highlights

These are the accomplishments of the Mectizan Donation Program and its partners in 2019.

MDP Annual Highlights 2019 (English) (6.76 MB)

Publication: Serological Evaluation of Onchocerciasis and Lymphatic Filariasis Elimination in the Bakoye and Falémé foci, Mali

This research article examines the Ov16 (onchocerciasis) and Wb123 (lymphatic filariasis) seroprevalence in the Bakoye and Falémé foci in Mali after 24 – 25 years of treatment.

Dolo et al., 2020 (1.05 MB)

Stamp Out Oncho – Cameroon 2019 (A Short Film)

This short film covers the movement to eliminate Onchocerciasis (river blindness) in Cameroon, Africa. Follow our Vimeo account for more video footage from the field.

Mectizan Program Notes – Winter 2020

For more information, please download and read the attached PDF.

Mectizan Program Notes – Winter 2020 (1.10 MB)

Publication: Challenges to Making the Decision to Stop Mass Drug Administration for Onchocerciasis: Lessons Learned from Nigeria

This editorial from Darin S. Evans raises important questions regarding the decision to stop mass drug administration (MDA) for countries with onchocerciasis as they approach transmission interruption.

Evans, 2020 (38.33 KB)
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