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Mectizan Expert Committee Statement on Potential Efficacy of Ivermectin on COVID-19

A report by Caly et al found that ivermectin has shown in vitro activity against SARS-COV-2 (COVID-19) in tissue culture with Vero-hSLAM cells. These findings are consistent with the activity of ivermectin previously reported against other viruses in vitro. However, the high concentration of ivermectin needed to produce anti-viral effects in laboratory tissue culture is far beyond dosage levels approved by the FDA for treatment of parasites in humans and known to be safe and well tolerated. Furthermore, the concentration is many times higher than dosage levels ever tested in humans. High doses in animal models have produced serious toxicity. These preliminary laboratory findings in tissue cultures are not sufficient to indicate that ivermectin will be of clinical benefit to reduce viral loads in COVID-19 patients.

Caly, L., et al., The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral research, 2020.

News, videos & resources

Get the latest on the Mectizan Donation Program

Annual Highlights

2019 Mectizan Donation Program Annual Highlights (English)

These are the accomplishments of the Mectizan Donation Program and its partners in 2019.

MDP Annual Highlights 2019 (English) (7.90 MB)

Annual Highlights

2019 Mectizan Donation Program Annual Highlights (French)

These are the accomplishments of the Mectizan Donation Program and its partners in 2019.

MDP Annual Highlights 2019 (French) (6.90 MB)

Documents

PAHO Recommendation regarding the use of Ivermectin as a treatment for COVID-19

A recent study informed that ivermectin was successfully used in vitro for the treatment of SARS-CoV-2 in experimentally infected cells and two preprint publications on observational clinical studies reported the apparent utility of ivermectin to treat patients with COVID-19 needing mechanical ventilation; neither of these studies were peer-reviewed nor formally published and one of them was later retracted.

PAHO Recommendation Regarding the Use of Ivermectin as a Treatment for COVID-19 (381.44 KB)

Videos

Video of microfilariae in the anterior chamber of the eye

This is footage[1] of microfilariae was captured in a 59-year-old man’s anterior chamber of the eye. The man lives in an onchocerciasis-endemic area in eastern Ghana.

Appearance of Mf in the anterior chamber (25.87 MB)
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