This article addresses elimination of onchocerciasis transmission in the Americas. With four of the six originally endemic American countries now WHO verified as having eliminated onchocerciasis transmission, and 95% of ivermectin treatments in the region halted, the regional focus is now on the remaining active transmission zone, called the Yanomami Area, on the border between Venezuela and Brazil. International Health, Volume 10, Issue suppl_1, 1 March 2018, Pages i71–i78.